Precision Health for Everyone
DxMapper screens for 12 life-threatening conditions, including six of the top seven causes of death in the U.S. By identifying potential risks 8.9–10.8 years earlier than standard age-based screening, it enables proactive, low-cost interventions.
Clinical Partnership
Developed in Collaboration with Mayo Clinic
DxMapper's genomic risk models are developed in collaboration with Mayo Clinic, ensuring clinical-grade accuracy and reliability.
Published Research
PRS Identifies Who Should Be Screened Earlier
High polygenic risk individuals reach the same disease incidence rate as the general population years — sometimes decades — before conventional guidelines would flag them.
| Condition | Standard Screening Age | PRS-Guided Age | Years Earlier |
|---|---|---|---|
| Abdominal Aortic Aneurysm (M) | 65 | 61 | 4 yrs |
| Breast Cancer (F) | 40 | 34 | 6 yrs |
| Colorectal Cancer | 50 | 42 | 8 yrs |
| Coronary Artery Disease | 40 | 35 | 5 yrs |
| Hypertension | 40 | 18 | 22 yrs |
| Prostate Cancer (M) | 55 | 50 | 5 yrs |
| Type 2 Diabetes | 35 | 25 | 10 yrs |
31%
reduction in breast cancer incidence
For high-PRS women identified early and offered preventive intervention.
† Chuong et al., Nature Communications, 2026. Based on UK Biobank cohort (n=332,664). High-risk defined as odds ratio >2.0.
Coverage
12 Critical Conditions
Click any condition to explore its polygenic risk profile and prevention strategies.
How It Works
From Risk to Resolution
Risk Identification
DNA sequencing identifies variants across 12 conditions — delivered through a simple cheek swab.
Early Intervention
Clinicians receive actionable reports to guide proactive screening, lifestyle changes, and preventive therapies.
Improved Health & Savings
Early detection prevents catastrophic outcomes — turning potential $100K+ claims into manageable, affordable interventions.
The Data
Redefining Early Detection
would not be flagged by standard clinical criteria alone
have elevated risk for at least one condition, based on DxMapper data
targeted by our genomic health program
Clinical Example
Sarah's Story
Before DxMapper
- No family history of colorectal cancer identified in standard intake
- Standard screening schedule — colonoscopy at age 50
- Genomic risk completely undetected by conventional methods
- High polygenic risk score undetected — no proactive screening initiated
After DxMapper
- High polygenic risk score for colorectal cancer identified via DxMapper
- Early colonoscopy ordered — Stage I polyp detected and removed
- Care team implements proactive screening strategy with ongoing surveillance
- Estimated $110,000+ in catastrophic claims avoided
Sarah is not an isolated case. 40% of high-risk patients have precancerous polyps that can be removed1 — DxMapper identifies members with elevated genomic risk.
1 Northcutt MJ, Shi Z, Zijlstra M, et al. Polygenic risk score is a predictor of adenomatous polyps at screening colonoscopy. BMC Gastroenterol. 2021;21(1):65. doi:10.1186/s12876-021-01645-4
Identify Hidden Risks Before They Become Claims
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